Kanuka is an evergreen tree belonging to the genus Kunzea in the Myrtaceae family, locally, its leaves are primarily consumed as herbal tea, and little is known about its physiological effects or chemical constituents. On the other hand, bile acids play a role in micellizing dietary fats and cholesterols, facilitating their absorption from the intestinal tract into the bloodstream. Therefore, bile acid micelles disruption (BAMD) could inhibit fatty acid absorption and possibly suppress obesity-related blood indexes and body weight gain. In the present study, we found a water-soluble Kanuka (Kunzea ericoides) leaf extract (KWE) that exhibited the following novel significant effects related with obesity: 1) potent BAMD activity (50% BAMD at 0.15 mg/mL); 2) reduced adipose tissue weights of perirenal, peritesticular mass weight compared with the control group, perirenal fat mass weight was significantly increased in the HFD group but was significantly reduced (p<0.05) in the HFD+KWE group, and intrahepatic fat content when compared to the control group, negligible changes were observed in the HFD group, while significantly reductions were observed in the HFD+KWE group; and 3) lowered blood indexes (total cholesterols and triglyceride levels) with reduction tendency towards body weight gain in male C57BL/6J mice. As far as we know, our present endeavor is the first documented study that showed KWE to elicit suppressive effects on obesity-related parameters in mice.
| Published in | International Journal of Nutrition and Food Sciences (Volume 14, Issue 6) |
| DOI | 10.11648/j.ijnfs.20251406.23 |
| Page(s) | 514-520 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Kanuka (Kunzea Ericoides), Bile Acid Micelles Disruption, Anti-obesity Effects, Mice
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APA Style
Yamaguchi, S., Yano, Y., Nozaki, T., Kato, M., Fujita, H. (2025). Novel Findings of Anti-obesity Effects of Kanuka (Kunzea Ericoides) Leaf Water Extract in Mice: Bile Acid Micelles Disruption Activity. International Journal of Nutrition and Food Sciences, 14(6), 514-520. https://doi.org/10.11648/j.ijnfs.20251406.23
ACS Style
Yamaguchi, S.; Yano, Y.; Nozaki, T.; Kato, M.; Fujita, H. Novel Findings of Anti-obesity Effects of Kanuka (Kunzea Ericoides) Leaf Water Extract in Mice: Bile Acid Micelles Disruption Activity. Int. J. Nutr. Food Sci. 2025, 14(6), 514-520. doi: 10.11648/j.ijnfs.20251406.23
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Download@article{10.11648/j.ijnfs.20251406.23,
author = {Sanaka Yamaguchi and Yoshihisa Yano and Tsutomu Nozaki and Masaki Kato and Hiroyuki Fujita},
title = {Novel Findings of Anti-obesity Effects of Kanuka (Kunzea Ericoides) Leaf Water Extract in Mice: Bile Acid Micelles Disruption Activity},
journal = {International Journal of Nutrition and Food Sciences},
volume = {14},
number = {6},
pages = {514-520},
doi = {10.11648/j.ijnfs.20251406.23},
url = {https://doi.org/10.11648/j.ijnfs.20251406.23},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20251406.23},
abstract = {Kanuka is an evergreen tree belonging to the genus Kunzea in the Myrtaceae family, locally, its leaves are primarily consumed as herbal tea, and little is known about its physiological effects or chemical constituents. On the other hand, bile acids play a role in micellizing dietary fats and cholesterols, facilitating their absorption from the intestinal tract into the bloodstream. Therefore, bile acid micelles disruption (BAMD) could inhibit fatty acid absorption and possibly suppress obesity-related blood indexes and body weight gain. In the present study, we found a water-soluble Kanuka (Kunzea ericoides) leaf extract (KWE) that exhibited the following novel significant effects related with obesity: 1) potent BAMD activity (50% BAMD at 0.15 mg/mL); 2) reduced adipose tissue weights of perirenal, peritesticular mass weight compared with the control group, perirenal fat mass weight was significantly increased in the HFD group but was significantly reduced (p<0.05) in the HFD+KWE group, and intrahepatic fat content when compared to the control group, negligible changes were observed in the HFD group, while significantly reductions were observed in the HFD+KWE group; and 3) lowered blood indexes (total cholesterols and triglyceride levels) with reduction tendency towards body weight gain in male C57BL/6J mice. As far as we know, our present endeavor is the first documented study that showed KWE to elicit suppressive effects on obesity-related parameters in mice.},
year = {2025}
}
TY - JOUR T1 - Novel Findings of Anti-obesity Effects of Kanuka (Kunzea Ericoides) Leaf Water Extract in Mice: Bile Acid Micelles Disruption Activity AU - Sanaka Yamaguchi AU - Yoshihisa Yano AU - Tsutomu Nozaki AU - Masaki Kato AU - Hiroyuki Fujita Y1 - 2025/12/30 PY - 2025 N1 - https://doi.org/10.11648/j.ijnfs.20251406.23 DO - 10.11648/j.ijnfs.20251406.23 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 514 EP - 520 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20251406.23 AB - Kanuka is an evergreen tree belonging to the genus Kunzea in the Myrtaceae family, locally, its leaves are primarily consumed as herbal tea, and little is known about its physiological effects or chemical constituents. On the other hand, bile acids play a role in micellizing dietary fats and cholesterols, facilitating their absorption from the intestinal tract into the bloodstream. Therefore, bile acid micelles disruption (BAMD) could inhibit fatty acid absorption and possibly suppress obesity-related blood indexes and body weight gain. In the present study, we found a water-soluble Kanuka (Kunzea ericoides) leaf extract (KWE) that exhibited the following novel significant effects related with obesity: 1) potent BAMD activity (50% BAMD at 0.15 mg/mL); 2) reduced adipose tissue weights of perirenal, peritesticular mass weight compared with the control group, perirenal fat mass weight was significantly increased in the HFD group but was significantly reduced (p<0.05) in the HFD+KWE group, and intrahepatic fat content when compared to the control group, negligible changes were observed in the HFD group, while significantly reductions were observed in the HFD+KWE group; and 3) lowered blood indexes (total cholesterols and triglyceride levels) with reduction tendency towards body weight gain in male C57BL/6J mice. As far as we know, our present endeavor is the first documented study that showed KWE to elicit suppressive effects on obesity-related parameters in mice. VL - 14 IS - 6 ER -
Department of Applied Biological Science, Kyoto University of Advanced Science, Kameoka, Japan
Department of Applied Biological Science, Kyoto University of Advanced Science, Kameoka, Japan
Research and Development Dept. BHN Co., Ltd., Tokyo, Japan
Research and Development Dept. BHN Co., Ltd., Tokyo, Japan
Department of Applied Biological Science, Kyoto University of Advanced Science, Kameoka, Japan
