Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report

Luis Fernando Cifuentes; Andrew Salzman

doi:doi:10.11648/j.ijnfs.20251404.12

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Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report

Luis Fernando Cifuentes^*

, Andrew Salzman

Published in International Journal of Nutrition and Food Sciences (Volume 14, Issue 4)

Received: 15 June 2025 Accepted: 26 June 2025 Published: 15 July 2025

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Abstract

The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.

Published in	International Journal of Nutrition and Food Sciences (Volume 14, Issue 4)
DOI	10.11648/j.ijnfs.20251404.12
Page(s)	193-198
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Nicotinamide Mononucleotide, Hydroxytyrosol, Ergothioneine, Resveratrol, Vitamin D_₃, Real-world Setting, Self-reported

References

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APA Style

Cifuentes, L. F., Salzman, A. (2025). Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. International Journal of Nutrition and Food Sciences, 14(4), 193-198. https://doi.org/10.11648/j.ijnfs.20251404.12

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ACS Style

Cifuentes, L. F.; Salzman, A. Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. Int. J. Nutr. Food Sci. 2025, 14(4), 193-198. doi: 10.11648/j.ijnfs.20251404.12

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AMA Style

Cifuentes LF, Salzman A. Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. Int J Nutr Food Sci. 2025;14(4):193-198. doi: 10.11648/j.ijnfs.20251404.12

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@article{10.11648/j.ijnfs.20251404.12,
  author = {Luis Fernando Cifuentes and Andrew Salzman},
  title = {Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report
},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {14},
  number = {4},
  pages = {193-198},
  doi = {10.11648/j.ijnfs.20251404.12},
  url = {https://doi.org/10.11648/j.ijnfs.20251404.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20251404.12},
  abstract = {The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.},
 year = {2025}
}

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TY  - JOUR
T1  - Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report

AU  - Luis Fernando Cifuentes
AU  - Andrew Salzman
Y1  - 2025/07/15
PY  - 2025
N1  - https://doi.org/10.11648/j.ijnfs.20251404.12
DO  - 10.11648/j.ijnfs.20251404.12
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
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EP  - 198
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20251404.12
AB  - The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.
VL  - 14
IS  - 4
ER  -

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Author Information

Luis Fernando Cifuentes

Research & Development, Wonderfeel Biosciences, San Francisco, USA

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http://orcid.org/0000-0002-3531-1007
Andrew Salzman

Research & Development, Wonderfeel Biosciences, San Francisco, USA

Contact Email

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APA Style

Cifuentes, L. F., Salzman, A. (2025). Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. International Journal of Nutrition and Food Sciences, 14(4), 193-198. https://doi.org/10.11648/j.ijnfs.20251404.12

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ACS Style

Cifuentes, L. F.; Salzman, A. Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. Int. J. Nutr. Food Sci. 2025, 14(4), 193-198. doi: 10.11648/j.ijnfs.20251404.12

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AMA Style

Cifuentes LF, Salzman A. Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report. Int J Nutr Food Sci. 2025;14(4):193-198. doi: 10.11648/j.ijnfs.20251404.12

Copy | Download

@article{10.11648/j.ijnfs.20251404.12,
  author = {Luis Fernando Cifuentes and Andrew Salzman},
  title = {Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report
},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {14},
  number = {4},
  pages = {193-198},
  doi = {10.11648/j.ijnfs.20251404.12},
  url = {https://doi.org/10.11648/j.ijnfs.20251404.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20251404.12},
  abstract = {The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Real-world User-reported Benefits of a Multi-ingredient NMN-based Supplement Targeting Age-related Decline: A Brief Report

AU  - Luis Fernando Cifuentes
AU  - Andrew Salzman
Y1  - 2025/07/15
PY  - 2025
N1  - https://doi.org/10.11648/j.ijnfs.20251404.12
DO  - 10.11648/j.ijnfs.20251404.12
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 193
EP  - 198
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20251404.12
AB  - The age-related decline in nicotinamide adenine dinucleotide (NAD⁺) contributes to mitochondrial dysfunction and oxidative stress, which may be mitigated by supplementation with NAD⁺ precursors such as nicotinamide mononucleotide (NMN). This retrospective observational study evaluated user-reported outcomes of a multi-ingredient supplement (NMN, hydroxytyrosol, ergothioneine, resveratrol, and vitamin D₃) using 196 self-reported experiences collected from the Wonderfeel Biosciences online platform (April 2022–September 2024). Among 196 analyzed users, 131 (66.8%) reported positive effects, primarily in the nervous (81%), integumentary (11%), muscular (4%), skeletal (2%), digestive (2%), and endocrine (1%) systems, while 31.6% noted neutral effects and 1.5% reported non-causal adverse events. These findings align with known mechanisms of NAD⁺ restoration and oxidative stress mitigation, suggesting complementary biological pathways. Although this real-world evidence highlights perceived improvements in energy, cognition, sleep, and skin health, the study’s limitations—including self-reported data, lack of demographic controls, and absence of biomarkers—necessitate confirmation through the prospective controlled clinical trial scheduled to commence in late 2025.
VL  - 14
IS  - 4
ER  -

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